The difference between ordinary kidney disease and Uremia
The difference between the two is whether the renal tubule is necrotic.
Why does nephrosis develop into uremia?
The scientists have found that a high metabolism in renal tubule can cause the generation of oxygen free radicals in the remaining nephron increased, free radical scavengers (such as glutathione) decreased further induced lipid peroxidation, resulting in cell and tissue damage, make a further loss of kidney necrosis.
Two: high metabolism in renal tubules can cause interstitial infiltration of lymph and mononuclear cells, and the release of some cytokines and growth factors, also leading to tubulointerstitial damage and stimulate interstitial fibroblasts, accelerate the fibrosis process.
Patients with excessive levels of alpha globulin are the most refractory in all Nephrotic syndrome because they represent renal tubular injuries.
Once the renal tubular disease becomes the main force of the kidney disease, then the nephrosis begins to evolve into uremia.
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